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Utiger

Kashin-Beck disease--expanding the spectrum of iodine-deficiency disorders.

Utiger RD.

N Engl J Med. 1998 Oct 15;339(16):1156-8.

"These findings suggest that Kashin-Beck disease results from the combination of selenium and iodine deficiency.  The Kashin-Beck type of osteoarthropathy is not a feature of endemic goiter, hypothyroid cretinism, or sporadic hypothyroidism in children....

"How might combined iodine and selenium deficiency affect cartilage?  One possibility is that growth-plate cartilage is not only especially dependent on locally produced triiodothyronine but also sensitive to oxidative damage.  Thus, deficiency of iodothyronine deiodinase and glutathione peroxidase might result in a combination of local thyroid hormone deficiency and cellular injury that could cause chondronecrosis.  The combined deficiency may affect other tissues as well, but if it does, the changes are less obvious than those of Kashin-Beck disease or of endemic cretinism...."

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