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Abraham
A Rebuttal of Dr. Gaby's Editorial on Iodine
Guy E. Abraham, MD and David Brownstein, MD
Townsend Letter for Doctors & Patients, October 2005
"In cases of increased mobilization of bromide from storage sites by orthoiodosupplementation and elevated serum bromide levels high enough to cause bromism, the administration of sodium chloride (6-10 gm/day) increases the renal clearance of bromide by 10 fold and minimizes the side effects of bromism. If orthoiodosupplementation results in elevated urine lead levels, together with increased bromide, ammonium chloride is preferable to sodium chloride since it is the chloride that increases renal clearance of bromide. The ammonium is metabolized to urea and has an acidifying effect, which increases renal clearance of lead also."
Iodine supplementation markedly increases urinary excretion of fluoride and bromide
Abraham GE
Townsend Newsletter, May, 2003
"While the debate continues, regarding benefits and adverse effects of fluoridation of our water supply and bromination of our food supply, what can one do to minimize the toxic effects of these 2 halides? One approach in decreasing the body burden of fluoride and bromide is orthoiodosupplementation, that is iodine/iodide supplementation in daily amount for whole body sufficiency."
"Is there a practical and simple way to lower the body's burden of fluoride and bromide? It has been known for sometime now that bromide competes with chloride in the extracellular space and that the total molar concentration of bromide plus chloride remains constant. (8) This concept has been used to decrease extracellular bromide levels by saline loading. However, the presence of bromide in the thyroid gland (9) and the central nervous system (10) suggests that there is another intracellular "pool" of bromide, not responding to chloride. In the thyroid gland, bromide competes with iodide for uptake, oxydation and organification.
The concept of orthoiodosupplementation and its clinical implications.
Abraham GE
The Original Internist, 11(2):29-38, 2004
"Pittman, et al, measured serum inorganic iodide levels in two groups of subjects: one group after iodization of salt, with an estimated daily intake of 750 mcg iodide, and the other group after iodization of bread, with a similar average daily intake of iodates. The expected mean serum level at equilibrium would be 17.2 mcg/L (750 mcg/43.5 L). The mean values observed by Pittman, et al, were 1.7 mcg/L for subjects after iodization of salt, and 18.7 mcg/L for subjects after iodization of bread. These data suggest that iodate in bread is very bioavailable, whereas only 10% of iodide in iodized salt were absorbed. On a molar basis, there is 30,000 times more chloride than iodide in iodized salt. Chloride competes with iodide for absorption in the intestinal tract. To this author's knowledge, the low bioavailability of iodide in iodized salt has never been reported."