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Spector
The effect of environmental temperature and potassium iodide supplementation on the excretion of iodine by normal human subjectsSpector H, Mitchell HH, Hamilton TS 1945
"1. The concentration of iodine in undiluted sweat was 0.95 mcg per 100 cc. A single dose of 2 mg. of KI increased the average concentration to 3.18 mcg per 100 cc., while 14 daily doses of 2 mg. of KI did not produce any significant additional increase.
2. Profuse sweating (averaging about 677 gm. per hour) increases dermal losses of iodine at high levels of iodine intake (2200 mcg per day, KI dosage), but at low levels (700 mcg per day) no consistent or considerable effect was observed. The effect of a sweating environment on urinary output of iodine was too variable to permit a general statement. Thus, no evidence was obtained that a sweating environment will increase iodine requirements.
3. At least three-fourths of the total iodine lost from the body was excreted through the urine. When the iodine intake was increased with KI supplementation, most of the increased excretion of iodine was lost through the urine.
4. The fecal excretion of iodine was greater under hot moist than under comfortable conditions at high levels of iodine intake, but not at the basal levels. Iodine dosage raised the fecal output of iodine significantly in a hot moist, but not in a comfortable, environment.
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